Tabbara K F, Vera-Cristo C L
Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Curr Opin Ophthalmol. 2000 Dec;11(6):449-54. doi: 10.1097/00055735-200012000-00011.
Sjögren syndrome is a chronic systemic disease characterized by polyglandular tissue destruction leading to keratoconjunctivitis sicca (KCS) and xerostomia. Patients with primary Sjögren syndrome show evidence of KCS and xerostomia, whereas patients with secondary Sjögren syndrome suffer from KCS, xerostomia, and an autoimmune disease, most commonly rheumatoid arthritis. Certain factors cause autoimmune dysregulation leading to destruction of the acinar cells and ductal epithelia with subsequent dry eyes and dry mouth. Activated lymphocytes in patients with autoimmune diseases appear to have selective homing into the lacrimal and salivary glands leading to tissue damage. Understanding the factors involved in the immune dysregulation may improve our diagnostic and therapeutic approaches in Sjögren syndrome. Current therapeutic measures include means to increase secretion, relieve symptoms, and repair damage of the ocular surface.
干燥综合征是一种慢性全身性疾病，其特征是多腺组织破坏，导致角结膜干燥症（KCS）和口干症。原发性干燥综合征患者有KCS和口干症的证据，而继发性干燥综合征患者则患有KCS、口干症和自身免疫性疾病，最常见的是类风湿性关节炎。某些因素导致自身免疫失调，导致腺泡细胞和导管上皮细胞破坏，随后出现干眼和口干。自身免疫性疾病患者中活化的淋巴细胞似乎选择性归巢至泪腺和唾液腺，导致组织损伤。了解免疫失调所涉及的因素可能会改善我们对干燥综合征的诊断和治疗方法。目前的治疗措施包括增加分泌、缓解症状以及修复眼表损伤的方法。
