老年人干燥综合征及其他口干症病因的最新进展
Update on Sjögren Syndrome and Other Causes of Sicca in Older Adults.
作者信息
Baer Alan N, Walitt Brian
机构信息
Division of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine, 5200 Eastern Avenue, Suite 4000, Mason Lord Center Tower, Baltimore, MD 21224, USA; National Institute of Dental and Craniofacial Research, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.
National Institute of Dental and Craniofacial Research, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.
出版信息
Rheum Dis Clin North Am. 2018 Aug;44(3):419-436. doi: 10.1016/j.rdc.2018.03.002.
Abstract
Dry eye and dry mouth symptoms are each reported by up to 30% of persons more than 65 years of age, particularly in women. Medication side effects are the most common contributing factors. The evaluation of these symptoms requires measures of ocular and oral dryness. Sjögren syndrome is the prototypical disease associated with dryness of the eyes and mouth and predominantly affects women in their perimenopausal and postmenopausal years. In addition to topical treatment of the mucosal dryness, patients with Sjögren syndrome may require treatment with systemic immunomodulatory and immunosuppressive agents to manage a variety of extraglandular manifestations.
摘要
65岁以上人群中，高达30%的人报告有干眼和口干症状，女性尤为常见。药物副作用是最常见的促成因素。对这些症状的评估需要测量眼干和口干情况。干燥综合征是与眼干和口干相关的典型疾病，主要影响围绝经期和绝经后女性。除了局部治疗黏膜干燥外，干燥综合征患者可能需要使用全身免疫调节和免疫抑制药物进行治疗，以控制各种腺外表现。
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