School of Population Health, The University of Western Australia.
J Epidemiol. 2014;24(2):146-53. doi: 10.2188/jea.je20130063. Epub 2014 Feb 15.
Data regarding the effects of tea, coffee, and milk on the risk of colorectal cancer are inconsistent. We investigated associations of tea, coffee, and milk consumption with colorectal cancer risk and attempted to determine if these exposures were differentially associated with the risks of proximal colon, distal colon, and rectal cancers.
Data from 854 incident cases and 948 controls were analyzed in a case-control study of colorectal cancer in Western Australia during 2005-07. Multivariable logistic regression was used to analyze the associations of black tea (with and without milk), green tea, herbal tea, hot coffee, iced coffee, and milk with colorectal cancer.
Consumption of 1 or more cups of herbal tea per week was associated with a significantly decreased risk of distal colon cancer (adjusted odds ratio, 0.37; 95% CI, 0.16-0.82; PTrend = 0.044), and consumption of 1 or more cups of iced coffee per week was associated with increased risk of rectal cancer (adjusted odds ratio, 1.52; 95% CI, 0.91-2.54; PTrend = 0.004). Neither herbal tea nor iced coffee was associated with the risk of proximal colon cancer. Hot coffee was associated with a possible increased risk of distal colon cancer. Black tea (with or without milk), green tea, decaffeinated coffee, and milk were not significantly associated with colorectal cancer risk.
Consumption of herbal tea was associated with reduced risk of distal colon cancer, and consumption of iced coffee was associated with increased rectal cancer risk.
关于茶、咖啡和牛奶对结直肠癌风险的影响的数据不一致。我们调查了茶、咖啡和牛奶的摄入与结直肠癌风险的关联，并试图确定这些暴露是否与近端结肠、远端结肠和直肠癌的风险存在差异关联。
在 2005-07 年期间，对西澳大利亚州的结直肠癌病例对照研究中，对 854 例病例和 948 例对照的数据进行了分析。多变量逻辑回归用于分析黑茶（加或不加牛奶）、绿茶、花草茶、热咖啡、冰咖啡和牛奶与结直肠癌的关联。
每周饮用 1 杯或更多杯花草茶与远端结肠癌风险显著降低相关（调整后的优势比，0.37；95%CI，0.16-0.82；PTrend = 0.044），每周饮用 1 杯或更多杯冰咖啡与直肠癌风险增加相关（调整后的优势比，1.52；95%CI，0.91-2.54；PTrend = 0.004）。无论是花草茶还是冰咖啡都与近端结肠癌风险无关。热咖啡与远端结肠癌的风险可能增加有关。黑茶（加或不加牛奶）、绿茶、脱咖啡因咖啡和牛奶与结直肠癌风险无显著关联。
饮用花草茶与降低远端结肠癌风险有关，饮用冰咖啡与增加直肠癌风险有关。
