Castello-Branco L R, Ortigão-de-Sampaio M B
Laboratório de Imunologia Clínica, Departamento de Imunologia, Instituto Oswaldo Cruz, Av. Brasil 4365, 21045-900 Rio de Janeiro, RJ, Brasil.
Mem Inst Oswaldo Cruz. 2000;95 Suppl 1:171-3. doi: 10.1590/s0074-02762000000700028.
Mucosal surfaces have a fundamental participation in many aspects of the human immunodeficiency virus (HIV) infection pathogenesis. In Brazilian HIV-1 infected subjects, loss of weight and appetite are among the most debilitating symptoms. In this review we describe a defined mucosal immunogen that has profound but transient effects on HIV viral load, and we suggest that gut associated lymphoid tissue under constant immunostimulation is likely to provide a major contribution to the total levels of HIV. We also show that hypermetabolism appears to play a role in the wasting process in Brazilian patients coinfected with HIV and tuberculosis.
黏膜表面在人类免疫缺陷病毒（HIV）感染发病机制的许多方面都有着重要作用。在巴西的HIV-1感染患者中，体重减轻和食欲不振是最使人虚弱的症状。在本综述中，我们描述了一种特定的黏膜免疫原，它对HIV病毒载量有深远但短暂的影响，并且我们认为持续受到免疫刺激的肠道相关淋巴组织可能对HIV的总体水平有重大影响。我们还表明，代谢亢进似乎在巴西同时感染HIV和结核病的患者的消瘦过程中起作用。
