Reisberger E M, Szeimies R M
Klinik und Poliklinik für Dermatologie, Klinikum der Universität Regensburg.
Med Klin (Munich). 2000 Nov 15;95(11):618-28. doi: 10.1007/pl00002074.
Considering the increased rate of mycotic infections of the nail, various concepts in the treatment of onychomycosis have been developed looking for a successful therapeutic approach.
An overview of the actual standards of topic and systemic treatment of onychomycosis depending on clinical findings, classification of onychomycosis and type of fungus will be presented.
Topical urea and bifonazole therapy was available in the past as well as systemic antimycotic therapy with just griseofulvin or ketoconazole. Nowadays a different spectrum of easily applicable, safe and effective therapeutic measures is on the physician's hands. Besides topical therapy with ciclopirox and amorolfine oral treatment with itraconazole, terbinafine and fluconazole is available. Combination therapy of terbinafine orally in addition with topical application of ciclopirox may possibly optimize the therapeutic approach considering the respective response rates however, no clinical study evaluating this hypothesis has been performed so far.
鉴于甲真菌病感染率上升，已开发出各种治疗甲癣的概念，以寻求成功的治疗方法。
将根据临床发现、甲癣分类和真菌类型，概述甲癣局部和全身治疗的实际标准。
过去有局部尿素和联苯苄唑疗法，以及仅用灰黄霉素或酮康唑的全身抗真菌疗法。如今，医生有一系列不同的易于应用、安全有效的治疗措施可供选择。除了环吡酮和阿莫罗芬的局部治疗外，还有伊曲康唑、特比萘芬和氟康唑的口服治疗。考虑到各自的有效率，特比萘芬口服联合环吡酮局部应用可能会优化治疗方法，然而，迄今为止尚未进行评估这一假设的临床研究。
