Csicsvari J, Hirase H, Mamiya A, Buzsáki G
Center for Molecular and Behavioral Neuroscience, Rutgers University, The State University of New Jersey, Newark 07102, USA.
Neuron. 2000 Nov;28(2):585-94. doi: 10.1016/s0896-6273(00)00135-5.
Transfer of neuronal patterns from the CA3 to CA1 region was studied by simultaneous recording of neuronal ensembles in the behaving rat. A nonlinear interaction among pyramidal neurons was observed during sharp wave (SPW)-related population bursts, with stronger synchrony associated with more widespread spatial coherence. SPW bursts emerged in the CA3a-b subregions and spread to CA3c before invading the CA1 area. Synchronous discharge of >10% of the CA3 within a 100 ms window was required to exert a detectable influence on CA1 pyramidal cells. Activity of some CA3 pyramidal neurons differentially predicted the ripple-related discharge of circumscribed groups of CA1 pyramidal cells. We suggest that, in SPW behavioral state, the coherent discharge of a small group of CA3 cells is the primary cause of spiking activity in CA1 pyramidal neurons.
通过同时记录行为大鼠的神经元集群，研究了神经元模式从CA3区到CA1区的传递。在尖波（SPW）相关的群体爆发期间，观察到锥体细胞之间存在非线性相互作用，更强的同步性与更广泛的空间相干性相关。SPW爆发出现在CA3a-b亚区，在侵入CA1区之前扩散到CA3c。在100毫秒窗口内，CA3中超过10%的同步放电才能对CA1锥体细胞产生可检测到的影响。一些CA3锥体细胞的活动差异地预测了CA1锥体细胞特定组的涟漪相关放电。我们认为，在SPW行为状态下，一小群CA3细胞的相干放电是CA1锥体细胞尖峰活动的主要原因。
