Turner C E
Department of Cell and Developmental Biology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, New York 13210, USA.
Nat Cell Biol. 2000 Dec;2(12):E231-6. doi: 10.1038/35046659.
To facilitate a rapid response to environmental change, cells use scaffolding - or adaptor - proteins to recruit key components of their signal-transduction machinery to specific subcellular locations. Paxillin is a multi-domain adaptor found at the interface between the plasma membrane and the actin cytoskeleton. Here it provides a platform for the integration and processing of adhesion- and growth factor-related signals.
为了促进对环境变化的快速反应，细胞利用支架蛋白或衔接蛋白将其信号转导机制的关键组分招募到特定的亚细胞位置。桩蛋白是一种多结构域衔接蛋白，位于质膜和肌动蛋白细胞骨架之间的界面处。在这里，它为整合和处理黏附及生长因子相关信号提供了一个平台。
