Turner C E, West K A, Brown M C
Department of Cell and Developmental Biology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, New York 13210, USA.
Curr Opin Cell Biol. 2001 Oct;13(5):593-9. doi: 10.1016/s0955-0674(00)00256-8.
Several new families of ARF GTPase activating proteins (ARF GAPs) have been described recently that associate with paxillin and other cytoskeletal and signaling proteins. Important insights have been gained regarding their subcellular distribution, enzymatic specificity and protein scaffold function. Evidence suggests an important role for ARF GAPs in mediating changes in the cell's actin cytoskeleton in response to adhesion and growth factor stimulation.
最近已经描述了几个新的ARF GTP酶激活蛋白（ARF GAPs）家族，它们与桩蛋白以及其他细胞骨架和信号蛋白相关联。在它们的亚细胞分布、酶特异性和蛋白质支架功能方面已经获得了重要的见解。有证据表明，ARF GAPs在介导细胞肌动蛋白细胞骨架响应黏附和生长因子刺激的变化中起重要作用。
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