肥厚性慢性硬脑膜炎作为颅颈区域的一种局限性免疫过程。

Hypertrophic chronic pachymeningitis as a localized immune process in the craniocervical region.

作者信息

Voller B, Vass K, Wanschitz J, Machold K, Asenbaum S, Hoberstorfer M, Auff E

机构信息

Department of Neurology, University of Vienna, Austria.

出版信息

Neurology. 2001 Jan 9;56(1):107-9. doi: 10.1212/wnl.56.1.107.

DOI:10.1212/wnl.56.1.107

PMID:11148246

Abstract

Hypertrophic chronic pachymeningitis (HCP) is a rare disorder that causes intracranial or spinal thickening of the dura mater. This report describes a patient with progressive HCP in the craniocervical region associated with signs of rheumatic disease. A ventricular-atrial shunt had to be inserted because of increased intracranial pressure. The patient improved after suboccipital craniotomy, C1 to C6 laminectomy, and removal of the thickened dura. Additional therapy with methotrexate stopped progression, which was documented by MRI and PET.

摘要

肥厚性慢性硬脑膜炎（HCP）是一种罕见的疾病，可导致颅内或脊髓硬脑膜增厚。本报告描述了一名颅颈区域患有进行性HCP并伴有风湿性疾病体征的患者。由于颅内压升高，不得不插入脑室-心房分流管。患者在枕下开颅、C1至C6椎板切除以及切除增厚的硬脑膜后病情有所改善。甲氨蝶呤的额外治疗阻止了病情进展，MRI和PET证实了这一点。