Avgerinou G, Gregoriou S, Rigopoulos D, Stratigos A, Kalogeromitros D, Katsambas A
1st Academic Department of Dermatology, University of Athens Medical School, A Sygros Hospital, Athens, Greece.
J Eur Acad Dermatol Venereol. 2008 Mar;22(3):320-3. doi: 10.1111/j.1468-3083.2007.02411.x. Epub 2007 Nov 12.
BACKGROUND Topical immunotherapy with diphencyprone (DPCP) is considered the most effective treatment of alopecia areata (AA).
To assess the efficacy of DPCP in the treatment of extensive or long-lasting AA in Greek patients.
Sixty-four patients with extensive and/or long-lasting AA were sensitized with 2% diphencyprone. During each weekly subsequent visit, patients were treated with gradually denser concentrations adjusted in order to maintain erythema and itch on the patient's scalp for 48 h. Patients' hair re-growth was evaluated every 3 months for 2 years.
Forty-five patients responded among the 54 completing therapy (83.3%). Initial response was observed 3.48 +/- 1.05 months after the initial treatment. Twenty patients among the responders achieved a grade 4 response, 15 patients achieved grade 3, 9 patients achieved grade 2, and 1 patient achieved a grade 1 response. The mean duration of treatment until maximum response was 6.14 +/- 1.48 months. Thirty-one patients (68.9%) had a relapse during follow-up and were treated again. The only adverse event among patients completing therapy was contact dermatitis of the face or neck (9 of 54) that resolved after topical corticosteroid application within 7 days. Statistical analysis did not establish any association among duration of AA, age, gender, atopic diathesis, nail involvement and presence of thyroid antibodies with response to treatment.
Treatment of Greek patients with AA with diphencyprone presents high response rates similar to those reported by previous studies. The treatment is adequately tolerated by most of the patients, and they are willing to repeat it in cases of relapse.
背景 二苯环丙烯酮（DPCP）局部免疫疗法被认为是斑秃（AA）最有效的治疗方法。
评估DPCP治疗希腊患者广泛性或持久性斑秃的疗效。
64例广泛性和/或持久性斑秃患者用2%二苯环丙烯酮进行致敏。在随后每周的每次就诊时，用逐渐增加浓度的药物对患者进行治疗，调整浓度以维持患者头皮红斑和瘙痒48小时。对患者的头发生长情况进行为期2年的每3个月一次的评估。
54例完成治疗的患者中有45例有反应（83.3%）。初始治疗后3.48±1.05个月观察到初始反应。有反应的患者中，20例达到4级反应，15例达到3级，9例达到2级，1例达到1级反应。直至达到最大反应的平均治疗持续时间为6.14±1.48个月。31例患者（68.9%）在随访期间复发并再次接受治疗。完成治疗的患者中唯一的不良事件是面部或颈部接触性皮炎（54例中有9例），局部应用皮质类固醇激素后7天内消退。统计分析未发现斑秃持续时间、年龄、性别、特应性素质、指甲受累情况和甲状腺抗体的存在与治疗反应之间存在任何关联。
用二苯环丙烯酮治疗希腊斑秃患者的反应率很高，与先前研究报道的相似。大多数患者对该治疗耐受性良好，复发时愿意再次接受治疗。
