组织学绒毛膜羊膜炎中的早期新生儿脑损伤
Early neonatal brain injury in histologic chorioamnionitis.
作者信息
Toti P, Laurini R N, Stumpo M, Picciolini E, Todros T, Tanganelli P, Buonocore G, Bracci R
机构信息
Department of Preventive Pediatrics and Neonatology, the Institute of Pathology, University of Siena, Siena, Italy.
出版信息
J Pediatr. 2001 Jan;138(1):101-4. doi: 10.1067/mpd.2001.109605.
The relation between clinical or histologic chorioamnionitis and early neonatal adverse neurologic outcome was investigated (n = 483). Histologic, but not clinical, evidence of chorioamnionitis was found to be a significant predictor of periventricular echodensity (odds ratio, 2.4; 95% CI, 1.8-3.2), echolucency (3.3; 1.9-5.6), ventriculomegaly (2.7; 1.8-4.2), intraventricular hemorrhage > or =3 (3.5; 2.4-5.2), and seizures (2.3; 1.4-3.7).
研究了临床或组织学绒毛膜羊膜炎与早期新生儿不良神经学结局之间的关系（n = 483）。结果发现，绒毛膜羊膜炎的组织学证据而非临床证据是脑室周围回声增强（优势比，2.4；95%可信区间，1.8 - 3.2）、回声透亮区（3.3；1.9 - 5.6）、脑室扩大（2.7；1.8 - 4.2）、脑室内出血≥3级（3.5；2.4 - 5.2）和癫痫发作（2.3；1.4 - 3.7）的显著预测因素。
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