Department of Neonatology, Children's National Hospital, Washington, DC, USA.
Department of Pediatrics, Division of Neonatology, Beverly Knight Olson Children's Hospital Navicent Health, Macon, GA, USA.
J Perinatol. 2021 Apr;41(4):843-849. doi: 10.1038/s41372-021-00954-6. Epub 2021 Mar 1.
The aim of this study was to examine the relationship between chorioamnionitis and vascular malperfusion on placental pathology and intraventricular hemorrhage (IVH) in premature and small for gestational age (SGA) infants.
A retrospective analysis of 263 infants ≤34 weeks gestation or ≤1800 g and their mothers was conducted by chart review for placental pathology and clinical data from 2014 to 2018. Unadjusted and adjusted odds ratios (OR) for the association of placental pathology with IVH were calculated.
Unadjusted OR showed an association between acute chorioamnionitis and IVH, but logistic regression analysis showed a non-significant adjusted OR between acute or chronic chorioamnionitis with IVH. Maternal vascular malperfusion was significantly associated with increased IVH when controlling for confounders.
Placental maternal vascular malperfusion is associated with the development of IVH in premature and SGA infants when controlling for other confounders.
本研究旨在探讨绒毛膜羊膜炎与血管灌注不良在早产儿和小于胎龄儿（SGA）脑室内出血（IVH）中的关系。
对 2014 年至 2018 年期间 263 名胎龄≤34 周或体重≤1800g 的婴儿及其母亲的病历进行回顾性分析，以评估胎盘病理和临床数据。计算胎盘病理与 IVH 之间的关联的未调整和调整比值比（OR）。
未调整的 OR 显示急性绒毛膜羊膜炎与 IVH 之间存在关联，但 logistic 回归分析显示急性或慢性绒毛膜羊膜炎与 IVH 之间的调整 OR 无统计学意义。在控制混杂因素后，母体血管灌注不良与 IVH 的发生显著相关。
在控制其他混杂因素后，胎盘母体血管灌注不良与早产儿和 SGA 婴儿 IVH 的发生有关。
