Nelson R W, Lynn R C, Wagner-Mann C C, Michels G M
Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis 95616, USA.
J Am Vet Med Assoc. 2001 Jan 1;218(1):38-42. doi: 10.2460/javma.2001.218.38.
To evaluate effects of protamine zinc insulin (PZI) on control of glycemia in cats with newly diagnosed diabetes mellitus or poorly controlled diabetes.
Clinical trial.
67 diabetic cats.
34 cats with newly diagnosed diabetes and 33 cats with poorly controlled diabetes were treated with PZI twice daily for 45 days. Control of glycemia was assessed on days 7, 14, 30, and 45 by evaluation of clinical response, change in body weight, serum fructosamine concentration, blood glucose concentration measured 1, 3, 5, 7, and 9 hours after administration of PZI, lowest blood glucose concentration, and mean blood glucose concentration during the 9-hour period after administration. Adjustments in dosage of PZI were made as needed to attain control of glycemia.
For all cats, a significant increase in mean dosage of PZI and significant decreases in 9-hour mean blood glucose concentration, lowest mean blood glucose concentration, and mean serum fructosamine concentration were detected. For cats with poorly controlled diabetes, 9-hour mean blood glucose concentration and mean serum fructosamine concentration were significantly decreased on day 45, compared with day 0. Ninety percent of owners reported improvement or resolution of clinical signs by day 45.
Results suggest that PZI was effective for control of glycemia in cats with newly diagnosed or poorly controlled diabetes and may be used as an initial treatment or as an alternative treatment in cats that do not respond to treatment with other types of insulin.
评估精蛋白锌胰岛素（PZI）对新诊断糖尿病或血糖控制不佳的猫的血糖控制效果。
临床试验。
67只糖尿病猫。
34只新诊断糖尿病猫和33只血糖控制不佳的猫每天接受两次PZI治疗，持续45天。在第7、14、30和45天，通过评估临床反应、体重变化、血清果糖胺浓度、注射PZI后1、3、5、7和9小时测量的血糖浓度、最低血糖浓度以及注射后9小时内的平均血糖浓度来评估血糖控制情况。根据需要调整PZI剂量以实现血糖控制。
对于所有猫，检测到PZI平均剂量显著增加，9小时平均血糖浓度、最低平均血糖浓度和平均血清果糖胺浓度显著降低。对于血糖控制不佳的猫，与第0天相比，第45天时9小时平均血糖浓度和平均血清果糖胺浓度显著降低。90%的猫主人报告在第45天时临床症状有所改善或消失。
结果表明，PZI对新诊断或血糖控制不佳的猫的血糖控制有效，可作为初始治疗或用于对其他类型胰岛素治疗无反应的猫的替代治疗。
