Elliott D A, Nelson R W, Reusch C E, Feldman E C, Neal L A
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis 95616, USA.
J Am Vet Med Assoc. 1999 Jun 15;214(12):1794-8.
To correlate serum fructosamine concentrations with established measures of glycemic control and to compare serum fructosamine and blood glycosylated hemoglobin (GHb) concentrations as a means for assessing glycemic control in diabetic cats.
Longitudinal cohort study.
26 healthy cats, 5 cats with stress-induced hyperglycemia, 15 untreated diabetic cats, and 36 treated diabetic cats.
Control of glycemia was classified and monitored and serum fructosamine and blood GHb concentrations were measured for 12 poorly controlled diabetic cats before and after improving glycemic control, 8 well-controlled treated diabetic cats before and after glycemic control deteriorated, and 5 cats with diabetes mellitus before and after onset of stress-induced hyperglycemia.
Mean serum fructosamine and blood GHb concentrations were significantly higher in untreated diabetic cats, compared with healthy cats, and in 24 poorly controlled diabetic cats, compared with 12 well-controlled diabetic cats. Mean serum fructosamine and blood GHb concentrations decreased significantly in 12 poorly controlled diabetic cats after improving glycemic control and increased significantly in 8 well-controlled diabetic cats after glycemic control deteriorated. A significant stress-induced increase in mean blood glucose concentration was evident 12 hours after insulin administration, but not in 5 docile diabetic cats that became fractious.
Serum fructosamine and blood GHb concentrations are clinically useful tools for monitoring control of glycemia in cats with diabetes mellitus.
将血清果糖胺浓度与已确立的血糖控制指标相关联，并比较血清果糖胺和糖化血红蛋白（GHb）浓度，以此作为评估糖尿病猫血糖控制情况的手段。
纵向队列研究。
26只健康猫、5只应激性高血糖猫、15只未经治疗的糖尿病猫和36只接受治疗的糖尿病猫。
对血糖控制情况进行分类和监测，并对12只血糖控制不佳的糖尿病猫在改善血糖控制前后、8只血糖控制良好的治疗糖尿病猫在血糖控制恶化前后以及5只糖尿病猫在应激性高血糖发作前后测量血清果糖胺和血液GHb浓度。
与健康猫相比，未经治疗的糖尿病猫的平均血清果糖胺和血液GHb浓度显著更高；与12只血糖控制良好的糖尿病猫相比，24只血糖控制不佳的糖尿病猫的平均血清果糖胺和血液GHb浓度显著更高。12只血糖控制不佳的糖尿病猫在改善血糖控制后，平均血清果糖胺和血液GHb浓度显著降低；8只血糖控制良好的糖尿病猫在血糖控制恶化后，平均血清果糖胺和血液GHb浓度显著升高。胰岛素注射12小时后，平均血糖浓度出现明显的应激性升高，但5只原本温顺的糖尿病猫变得烦躁时则未出现这种情况。
血清果糖胺和血液GHb浓度是监测糖尿病猫血糖控制情况的临床有用工具。
