Carr A B, Gerard D A, Larsen P E
Mayo Graduate School of Medicine, Department of Dental Specialties, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Int J Oral Maxillofac Implants. 2000 Nov-Dec;15(6):785-91.
In an effort to better understand the supporting anatomy for unloaded endosseous dental implants, this study focused on the histomorphometric analysis of 3 different types of implants placed into non-human primate jaws and allowed to heal for 6 months. This report describes data from 24 screw-type dental implants placed in edentulated (2 months healing time) posterior arches of 4 adult female baboons. Three different implants were placed and allowed to heal for 6 months prior to processing for evaluation: commercially pure titanium (n = 8), titanium alloy (n = 8), and titanium plasma-sprayed (n = 8). Circumferential bone-implant interface sampling from 6 regions along the entire length of each implant was obtained for evaluation of percent bone-implant contact (%BIC) and percent bone area (%BA), within 3 mm of the implant. Data were collected (reliability of 1.6% for both parameters) and analyzed by an observer blinded to implant material using IMAGE analysis software for differences between jaws, implant biomaterials, and jaw/biomaterial (analysis of variance, pairwise comparison using least squares method with Bonferroni adjustment). The results indicated that the overall mean %BIC was 55.8 and mean %BA was 48.1. Maxillary and mandibular differences for both parameters were statistically significantly different: %BIC in maxilla 50.8, in mandible 60.8; %BA in maxilla 43.6, in mandible 52.6 (both significant at the P < .05 level). The biomaterial analyses revealed no significant differences between the different implants for %BIC or %BA. The trend observed--that mandibular values were greater than maxillary values for the overall jaw comparisons--was found to be consistent at the jaw/biomaterial level, although the small sample size limited statistical power. These data, along with data from a previous 3-month study, provide insight into baseline supporting anatomy for dental implants.
为了更好地了解无负载骨内牙种植体的支持性解剖结构,本研究着重对植入非人灵长类动物颌骨的3种不同类型种植体进行组织形态计量学分析,并使其愈合6个月。本报告描述了24枚螺钉型牙种植体的数据,这些种植体植入4只成年雌性狒狒缺牙(愈合时间2个月)的后牙弓。植入3种不同的种植体并使其愈合6个月后进行处理以进行评估:商业纯钛(n = 8)、钛合金(n = 8)和钛等离子喷涂(n = 8)。从每个种植体全长的6个区域获取周向骨 - 种植体界面样本,以评估种植体3mm范围内的骨 - 种植体接触百分比(%BIC)和骨面积百分比(%BA)。收集数据(两个参数的可靠性均为1.6%),并由对种植体材料不知情的观察者使用图像分析软件进行分析,以比较颌骨、种植体生物材料以及颌骨/生物材料之间的差异(方差分析,使用最小二乘法并进行Bonferroni校正的成对比较)。结果表明,总体平均%BIC为55.8,平均%BA为48.1。两个参数在上颌和下颌之间的差异具有统计学意义:上颌%BIC为50.8,下颌为60.8;上颌%BA为43.6,下颌为52.6(均在P < .05水平上具有显著性)。生物材料分析显示,不同种植体之间的%BIC或%BA无显著差异。观察到的趋势——在整体颌骨比较中下颌值大于上颌值——在颌骨/生物材料水平上也是一致的,尽管样本量小限制了统计效力。这些数据,连同之前一项为期3个月研究的数据,为牙种植体的基线支持性解剖结构提供了见解。