Daligcon B C, Oyama J
Am J Physiol. 1975 Mar;228(3):742-6. doi: 10.1152/ajplegacy.1975.228.3.742.
Weaning female Sprague-Dawley rats were exposed to 2.76 or 4.15 G for periods ranging from 2 to 20 wk. The isolated diaphragm tissues from these rats were studied in vitro to determine the uptake of glucose and its utilization to CO2 and glycogen. The diaphragm muscle tissues obtained from centrifuged rats showed higher rates of glucose uptake and 14CO2 production from [U-14C]glucose than those obtained from noncentrifuged controls, but no significant differences in the rate of incorporation of [U-14C]glucose into glycogen were observed. Rats centrifuged for 12 wk at 4.15 G continued to show an increase in diaphragm tissue glucose uptake for periods up to 2 wk after return to normal gravity. The stimulating effect of insulin on the uptake of glucose and its incorporation into glycogen was much higher in the diaphragms of centrifuged rats. From the results of this study, it is concluded that one of the adaptive responses of rats to chronic centrifugation is an increase in glucose metabolism of their muscle tissues.
将断奶的雌性斯普拉格-道利大鼠暴露于2.76或4.15 G的环境中2至20周。对这些大鼠分离出的膈肌组织进行体外研究，以确定葡萄糖的摄取及其向二氧化碳和糖原的利用情况。与未离心的对照组相比，从离心后的大鼠获得的膈肌组织显示出更高的葡萄糖摄取率和[U-14C]葡萄糖生成14CO2的速率，但在[U-14C]葡萄糖掺入糖原的速率方面未观察到显著差异。在4.15 G下离心12周的大鼠在恢复正常重力后长达2周的时间内，膈肌组织葡萄糖摄取持续增加。胰岛素对离心大鼠膈肌中葡萄糖摄取及其掺入糖原的刺激作用要高得多。从这项研究的结果可以得出结论，大鼠对慢性离心的适应性反应之一是其肌肉组织葡萄糖代谢增加。
