胰岛素对离体大鼠膈肌中氨基葡萄糖代谢的影响。
The influence of insulin on the metabolism of glucosamine in the isolated rat diaphragm muscle.
作者信息
Beloff-Chain A, Chain E B, Rookledge K A
出版信息
Biochem J. 1970 Aug;119(1):27-30. doi: 10.1042/bj1190027.
Abstract
- The influence of insulin on the metabolism of [1-(14)C]glucosamine by diaphragm muscle from normal rats and rats rendered diabetic with streptozotocin has been studied. 2. The glucosamine was converted into glucosamine 1-phosphate, glucosamine 6-phosphate, glycogen, lactate and small amounts of other unidentified intermediates. 3. Insulin increased the incorporation of (14)C into glycogen in both the normal and diabetic muscle, but did not increase the formation of the glucosamine phosphate esters. 4. The (14)C content in the glycogen was present partly as glucose and partly as glucosamine; there was significantly more [(14)C]glucose in the glycogen of the diabetic muscle than in that of the normal muscle.
摘要
- 研究了胰岛素对正常大鼠及用链脲佐菌素诱导糖尿病大鼠膈肌中[1-(14)C]葡糖胺代谢的影响。2. 葡糖胺被转化为葡糖胺-1-磷酸、葡糖胺-6-磷酸、糖原、乳酸及少量其他未鉴定的中间产物。3. 胰岛素增加了正常和糖尿病肌肉中(14)C掺入糖原的量，但未增加磷酸葡糖胺酯的形成。4. 糖原中的(14)C含量部分以葡萄糖形式存在，部分以葡糖胺形式存在；糖尿病肌肉糖原中的[(14)C]葡萄糖明显多于正常肌肉糖原中的[(14)C]葡萄糖。
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The influence of insulin on the metabolism of glucosamine in the isolated rat diaphragm muscle.胰岛素对离体大鼠膈肌中氨基葡萄糖代谢的影响。
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本文引用的文献
1
An improved method for the colorimetric determination of phosphate.一种改进的比色法测定磷酸盐的方法。
Biochem J. 1938 Feb;32(2):295-8. doi: 10.1042/bj0320295.
2
A colorimetric method for the determination of glucosamine and chondrosamine.一种用于测定氨基葡萄糖和软骨糖胺的比色法。
Biochem J. 1933;27(6):1824-8. doi: 10.1042/bj0271824.
3
Effect of epinephrine on rat diaphragm.肾上腺素对大鼠膈肌的作用。
J Biol Chem. 1950 Dec;187(2):769-76.
4
The influence of insulin on carbohydrate metabolism in the isolated diaphragm muscle of normal and alloxan diabetic rats.胰岛素对正常及四氧嘧啶糖尿病大鼠离体膈肌碳水化合物代谢的影响。
Proc R Soc Lond B Biol Sci. 1955 May 17;143(913):481-503. doi: 10.1098/rspb.1955.0025.
5
Studies on the relationships between insulin, glucosamine, and glucose in rat diaphragms.大鼠膈肌中胰岛素、氨基葡萄糖和葡萄糖之间关系的研究。
J Biol Chem. 1955 Aug;215(2):803-8.
6
Action of phosphoglucomutase on D-glucosamine-6-phosphate.磷酸葡萄糖变位酶对6-磷酸-D-葡糖胺的作用。
J Biol Chem. 1953 Oct;204(2):877-89.
7
Studies on uridine-diphosphate-glucose.尿苷二磷酸葡萄糖的研究。
Biochem J. 1952 Jun;51(3):426-30. doi: 10.1042/bj0510426.
8
The metabolism of glucose in diaphragm muscle from normal rats, from streptozotocin-treated diabetic rats and from rats treated with anti-insulin serum.正常大鼠、链脲佐菌素处理的糖尿病大鼠以及抗胰岛素血清处理的大鼠膈肌中葡萄糖的代谢。
Biochem J. 1968 Dec;110(3):529-32. doi: 10.1042/bj1100529.
9
Antagonistic actions between dibutyryl adenosine-3',5'-cyclic monophosphate and insulin on the metabolism of the surviving rat diaphragm.
Biochem Biophys Res Commun. 1969 Feb 7;34(3):283-90. doi: 10.1016/0006-291x(69)90829-8.
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