Post R M
Am J Psychiatry. 1975 Mar;132(3):225-31. doi: 10.1176/ajp.132.3.225.
The author describes an orderly progression of clinical syndromes (euphoria, dysphoria, paranoid psychosis) with cocaine use that is related to dosage, chronicity, and genetic and experiential predispositions. That affective alternations are caused by a drug which also produces a schizophreniform psychosis suggests a continuum with implications for understanding the endogenous psychoses. The author emphasizes that alternations in the same neurotransmitter substances may be involved in these multiple psychiatric syndromes, which contrasts with previous "one illness, one transmitter" models.
作者描述了使用可卡因时临床综合征（欣快、烦躁不安、偏执性精神病）的有序进展，这与剂量、慢性使用以及遗传和经验易感性有关。一种也会引发精神分裂症样精神病的药物导致情感交替，这表明存在一种连续性，对理解内源性精神病具有启示意义。作者强调，这些多种精神综合征可能涉及相同神经递质物质的变化，这与先前的“一种疾病，一种递质”模型形成对比。
