半子囊菌酵母的基因组探索：20. 与酿酒酵母相比基因冗余的进化。

Genomic exploration of the hemiascomycetous yeasts: 20. Evolution of gene redundancy compared to Saccharomyces cerevisiae.

作者信息

Llorente B, Durrens P, Malpertuy A, Aigle M, Artiguenave F, Blandin G, Bolotin-Fukuhara M, Bon E, Brottier P, Casaregola S, Dujon B, de Montigny J, Lépingle A, Neuvéglise C, Ozier-Kalogeropoulos O, Potier S, Saurin W, Tekaia F, Toffano-Nioche C, Wésolowski-Louvel M, Wincker P, Weissenbach J, Souciet J, Gaillardin C

机构信息

Unité de Génétique Moléculaire des Levures (URA 2171 du CNRS, UFR 927 Université Pierre et Marie Curie), Institut Pasteur, Paris, France.

出版信息

FEBS Lett. 2000 Dec 22;487(1):122-33. doi: 10.1016/s0014-5793(00)02291-2.

DOI:10.1016/s0014-5793(00)02291-2

PMID:11152895

Abstract

We have evaluated the degree of gene redundancy in the nuclear genomes of 13 hemiascomycetous yeast species. Saccharomyces cerevisiae singletons and gene families appear generally conserved in these species as singletons and families of similar size, respectively. Variations of the number of homologues with respect to that expected affect from 7 to less than 24% of each genome. Since S. cerevisiae homologues represent the majority of the genes identified in the genomes studied, the overall degree of gene redundancy seems conserved across all species. This is best explained by a dynamic equilibrium resulting from numerous events of gene duplication and deletion rather than by a massive duplication event occurring in some lineages and not in others.

摘要

我们评估了13种半子囊菌酵母物种核基因组中的基因冗余程度。酿酒酵母中的单拷贝基因和基因家族在这些物种中通常分别作为单拷贝基因和大小相似的基因家族而保守存在。相对于预期数量的同源基因数量变化影响每个基因组的7%至不到24%。由于酿酒酵母同源基因代表了所研究基因组中鉴定出的大多数基因，因此基因冗余的总体程度似乎在所有物种中都是保守的。这最好用由大量基因复制和缺失事件导致的动态平衡来解释，而不是由某些谱系中发生而其他谱系中未发生的大规模复制事件来解释。