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聚-L/D-丙交酯(PLDLA)96/4与聚乙醇酸酯(Maxon)缝线的强度特性比较:体外、皮下及兔跟腱实验

Comparison of strength properties of poly-L/D-lactide (PLDLA) 96/4 and polyglyconate (Maxon) sutures: in vitro, in the subcutis, and in the achilles tendon of rabbits.

作者信息

Kangas J, Paasimaa S, Mäkelä P, Leppilahti J, Törmälä P, Waris T, Ashammakhi N

机构信息

Department of Surgery, Oulu University Hospital, Oulu, Finland.

出版信息

J Biomed Mater Res. 2001;58(1):121-6. doi: 10.1002/1097-4636(2001)58:1<121::aid-jbm180>3.0.co;2-z.

Abstract

Achilles tendon rupture is a common injury. Absorbable sutures are not commonly used because of their limited strength properties. Recently, sutures with prolonged strength retention properties have been developed. The aim of the study is to test the mechanical properties of recently developed poly-L/D-lactide (PLDLA) sutures in comparison with polyglyconate (Maxon) sutures. PLDLA (0.2 mm thick) and Maxon (4.0) sutures were studied in vitro by immersion in a buffered saline solution (pH 7.4). Tensile strength tests were done on sutures retrieved after 1-26 weeks. In vivo, they were implanted in the subcutis of 32 rabbits. Tensile strength tests were done on sutures retrieved after 1-6 weeks. The sutures were also used to repair the Achilles tendon in rabbits. Maximum force before breaking and percentage elongation of tendons were determined. Although PLDLA had a lower initial tensile strength than Maxon, PLDLA showed more prolonged tensile strength retention than Maxon. Tendons repaired with PLDLA, however, had a lower strength than Maxon-repaired tendons at six weeks (insignificant difference). PLDLA has more prolonged tensile strength properties compared with Maxon. Thus, PLDLA offers an alternative to Maxon in repair of the Achilles tendon.

摘要

跟腱断裂是一种常见损伤。由于可吸收缝线的强度特性有限,其并不常用。近来,已研发出具有延长强度保留特性的缝线。本研究的目的是测试新研发的聚-L/D-丙交酯(PLDLA)缝线与聚甘醇酸酯(Maxon)缝线相比的力学性能。将PLDLA(0.2毫米厚)和Maxon(4.0)缝线浸入缓冲盐溶液(pH 7.4)中进行体外研究。对1 - 26周后取出的缝线进行拉伸强度测试。在体内,将它们植入32只兔子的皮下组织。对1 - 6周后取出的缝线进行拉伸强度测试。这些缝线还用于修复兔子的跟腱。测定了肌腱断裂前的最大力和伸长百分比。虽然PLDLA的初始拉伸强度低于Maxon,但PLDLA的拉伸强度保留时间比Maxon更长。然而,在六周时,用PLDLA修复的肌腱强度低于用Maxon修复的肌腱(差异不显著)。与Maxon相比,PLDLA具有更长的拉伸强度特性。因此,在跟腱修复中,PLDLA为Maxon提供了一种替代选择。

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