[纤维肌痛综合征生理病理学中细胞内钙和镁离子的变化]
[Changes in intracellular calcium and magnesium ions in the physiopathology of the fybromyalgia syndrome].
作者信息
Magaldi M, Moltoni L, Biasi G, Marcolongo R
机构信息
Istituto di Reumatologia, Policlinico Le Scotte, Viale Bracci, 1-53100 Siena.
出版信息
Minerva Med. 2000 Jul-Aug;91(7-8):137-40.
BACKGROUND
Calcium and magnesium ions play a key role in the physiology of muscular contraction: changes in calcium ions concentration may be involved in the pathogenesis of fibromyalgia. Since the plasmatic levels of calcium and magnesium in fibromyalgia patients is always in the normal range, it seemed interesting to evaluate the intracellular calcium and magnesium concentration.
METHODS
The study was carried out on two groups of subjects: 100 affected by fibromyalgia and 40 healthy controls.
RESULTS
The results obtained show that in fibromyalgia patients the intracellular calcium and magnesium concentration seems to be a peculiar characteristics of fibromyalgia patients and may be potentially responsible for muscular hypertonus.
CONCLUSIONS
It is still to be confirmed the effective role of this anomaly in the pathophysiology of fibromyalgia and the potential role of drugs active on calcium homeostatis.
背景
钙和镁离子在肌肉收缩生理过程中起关键作用：钙离子浓度变化可能与纤维肌痛的发病机制有关。由于纤维肌痛患者血浆中钙和镁水平始终在正常范围内，因此评估细胞内钙和镁浓度似乎很有意义。
方法
该研究针对两组受试者进行：100名纤维肌痛患者和40名健康对照者。
结果
所得结果表明，纤维肌痛患者细胞内钙和镁浓度似乎是纤维肌痛患者的一个特殊特征，可能是肌肉张力亢进的潜在原因。
结论
这种异常在纤维肌痛病理生理学中的实际作用以及对钙稳态有活性的药物的潜在作用仍有待证实。
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