Biocina-Lukenda Dolores, Blazić-Potocki Zita, Lukenda Josip, Potocki-Karacić Tanja
School of Medicine, Division of Dental Medicine, University of Split, Split, Croatia.
Coll Antropol. 2009 Mar;33(1):93-7.
The concentration levels of salivary calcium, magnesium and zinc can vary in different localized oral, as well as systemic diseases and conditions. So far changes in the concentration levels of specific electrolytes in stimulated parotid saliva in HIV-positive/AIDS patients have been proven. The objective of this research was not only to study the concentration levels of calcium in non-stimulated total saliva, but also the concentration levels of magnesium and zinc, which have not been studied so far, and the influence of antiretroviral therapy (HAART). This research was conducted on 60 healthy subjects with an average age of 40.4 years, and 60 HIV-positive patients with an average age of 43.7 years, 45 of whom took HAART therapy. The concentration levels of calcium, magnesium and zinc in saliva were determined by means of an atomic absorption spectrophotometry. No significant differences in the levels of excreted saliva/5 minutes (p = 0.116), the concentration levels of salivary calcium (p = 0.713), magnesium (p = 0.600), nor zinc (p = 0.162) were found between HIV-positive patients and the control group. No any correlation was determined between all three types of electrolytes and the number of CD4+ cells, nor the number of HIV-virus copies in peripheral blood of patients. Within the HIV-positive group, with respect to HAART therapy, no differences were found in the concentration levels of salivary magnesium (p = 0.588), nor zinc (p = 0.096). However, the concentration levels of salivary calcium were significantly higher in HIV-positive patients who underwent HAART treatment (p = 0.004). The results of this research show that HIV, as a systematic infection, does not cause changes in the excretion of magnesium, zinc nor calcium in non-stimulated total saliva. Furthermore, it has been proven that HAART treatment does not cause changes in the concentration levels of magnesium or zinc, but can cause an elevation in the concentration level of saliva, which could be related to the calcium mobilization in blood.
唾液中钙、镁和锌的浓度水平在不同的局部口腔疾病以及全身性疾病和状况中可能会有所不同。到目前为止，已证实HIV阳性/艾滋病患者刺激腮腺唾液中特定电解质的浓度水平会发生变化。本研究的目的不仅是研究非刺激性全唾液中钙的浓度水平，还包括镁和锌的浓度水平（目前尚未对其进行研究）以及抗逆转录病毒疗法（HAART）的影响。本研究针对60名平均年龄为40.4岁的健康受试者以及60名平均年龄为43.7岁的HIV阳性患者进行，其中45名患者接受了HAART治疗。通过原子吸收分光光度法测定唾液中钙、镁和锌的浓度水平。在HIV阳性患者和对照组之间，未发现5分钟唾液分泌量水平（p = 0.116）、唾液钙浓度水平（p = 0.713）、镁浓度水平（p = 0.600）以及锌浓度水平（p = 0.162）存在显著差异。未确定所有三种类型的电解质与患者外周血中CD4 +细胞数量或HIV病毒拷贝数之间存在任何相关性。在HIV阳性组中，就HAART治疗而言，唾液镁浓度水平（p = 0.588）和锌浓度水平（p = 0.096）未发现差异。然而，接受HAART治疗的HIV阳性患者唾液钙浓度水平显著更高（p = 0.004）。本研究结果表明，HIV作为一种全身性感染，不会导致非刺激性全唾液中镁、锌和钙的排泄发生变化。此外，已证实HAART治疗不会导致镁或锌浓度水平发生变化，但会导致唾液浓度水平升高，这可能与血液中的钙动员有关。
