Huang P C, Chen J T, Chia-Man C, Kwan P C, Ho W L
Department of Pathology, Taichung Hospital Department of Health, 199, Section 1, San-Min Road, Taichung, Taiwan.
J Formos Med Assoc. 2000 Dec;99(12):948-51.
Benign metastasizing leiomyoma (BML) refers to benign pulmonary neoplasm associated with a previous or coincident history of uterine leiomyomata. We report the case of a 56-year-old postmenopausal woman with a 4-year history of multiple benign leiomyomatous lesions in bilateral lungs and the uterus. The tumor cells from the lungs and uterus were focally immunoreactive for HMB-45 antibody and progesterone receptor. Immunoreactivity to HMB-45 is well known in smooth muscle cells of hamartomatous neoplasms, such as angiomyolipoma and lymphangioleiomyomatosis, but has not been reported in BML previously. These features suggest a multifocal hamartomatous histogenesis rather than metastasis in the present case.
良性转移性平滑肌瘤（BML）是指与既往或同时存在的子宫平滑肌瘤病史相关的良性肺肿瘤。我们报告了一例56岁绝经后女性，其双侧肺和子宫有4年的多发性良性平滑肌瘤性病变病史。肺和子宫的肿瘤细胞对HMB-45抗体和孕激素受体呈局灶性免疫反应。HMB-45的免疫反应在错构瘤性肿瘤如血管平滑肌脂肪瘤和淋巴管平滑肌瘤病的平滑肌细胞中是众所周知的，但此前在BML中尚未见报道。这些特征提示本例为多灶性错构瘤性组织发生而非转移。
