Reis-Filho J S, Carrilho C, Valenti C, Leitão D, Ribeiro C A, Ribeiro S G, Schmitt F C
Institute of Pathology and Molecular Immunology at Porto University, IPATIMUP, Portugal.
Pathol Res Pract. 2000;196(12):835-40. doi: 10.1016/S0344-0338(00)80084-9.
To evaluate the immunohistochemical expression of thyroid transcription factor 1 (TTF1) in primary and metastatic pulmonary adenocarcinomas, and test the diagnostic accuracy of this antibody, two surgical pathologists independently evaluated 34 cases of adenocarcinomas in the lung without clinical data and tried to distinguish between primary and metastatic cases using histological criteria exclusively. Thirteen cases were primary in the lung and 21 were metastases of extrapulmonary adenocarcinomas: 6 from the endometrium, 4 from the ovary, 3 from the colon, 2 from the kidney, 2 from the breast, 2 from the liver and 1 from the prostate. Afterward, the immunoreactivity of TTF1 in these neoplasms was evaluated and correlated with morphological and clinical data. The two pathologists were able to diagnose only 5 out of 13 cases of primary lung adenocarcinomas (sensitivity of 38.46%) and also misdiagnosed two primary malignancies as metastases. After correlation with TTF1 data, the sensitivity increased to 61.53%. The specificity of TTF1 was 100%. In conclusion, TTF1 is a highly specific marker for primary lung adenocarcinomas, and should be included in a panel of antibodies for the differential diagnosis between primary and metastatic adenocarcinomas of the lung.
为评估甲状腺转录因子1（TTF1）在原发性和转移性肺腺癌中的免疫组化表达，并检测该抗体的诊断准确性，两名外科病理学家独立评估了34例无临床资料的肺腺癌病例，并试图仅使用组织学标准区分原发性和转移性病例。其中13例为原发性肺癌，21例为肺外腺癌转移：6例来自子宫内膜，4例来自卵巢，3例来自结肠，2例来自肾脏，2例来自乳腺，2例来自肝脏，1例来自前列腺。随后，评估了这些肿瘤中TTF1的免疫反应性，并将其与形态学和临床资料相关联。两名病理学家仅能诊断出13例原发性肺腺癌中的5例（敏感性为38.46%），还将2例原发性恶性肿瘤误诊为转移瘤。与TTF1数据相关联后，敏感性提高到61.53%。TTF1的特异性为100%。总之，TTF1是原发性肺腺癌的高度特异性标志物，应纳入用于肺原发性和转移性腺癌鉴别诊断的抗体组合中。
