Grunbaum B W, Leon H A
Aviat Space Environ Med. 1975 Feb;46(2):136-40.
Changes in plasma haptoglobin, total protein, hematocrit, and hemoglobin content of blood were studied in rats at various times during a 7-d exposure to oxygen at 760 torr. Plasma haptoglobin and other plasma proteins were fractionated and quantitatively evaluated for a 3-d exposure period. Total protein and haptoglobin were depressed after 7 d of exposure. Significant changes were not noted before this time. With a 3-d exposure, for which plasma proteins were fractionated, fibrinogen showed a considerable increase whereas albumin, gamma globulins, and the beta 1 globulin fraction decreased significantly. Individual variations in albumin and haptoglobin were correlated inversely to the hematocrit. These variations indicate that the altered composition of the plasma protein is due, in part, to a variable loss of the various plasma protein fractions as a result of increased vascular permeability.
在760托氧气环境下对大鼠进行7天暴露实验的不同时间点，研究了血浆中触珠蛋白、总蛋白、血细胞比容和血红蛋白含量的变化。在3天的暴露期内，对血浆触珠蛋白和其他血浆蛋白进行了分离和定量评估。暴露7天后，总蛋白和触珠蛋白降低。在此之前未观察到显著变化。在进行血浆蛋白分离的3天暴露实验中，纤维蛋白原显著增加，而白蛋白、γ球蛋白和β1球蛋白组分显著减少。白蛋白和触珠蛋白的个体差异与血细胞比容呈负相关。这些变化表明，血浆蛋白组成的改变部分是由于血管通透性增加导致各种血浆蛋白组分的可变损失。
