Chow K M, Lai F M, Wang A Y, Chan Y L, Tang N L, Li P K
Departments of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China.
Am J Kidney Dis. 2001 Feb;37(2):E17. doi: 10.1053/ajkd.2001.21361.
A Chinese patient with paroxysmal nocturnal hemoglobinuria (PNH) developed acute nonoliguric renal failure with intercurrent urinary tract infection and hemolysis. There was no evidence of renal vein thrombosis. Renal biopsy showed features of acute tubular necrosis (ATN) and hemosiderosis. Magnetic resonance imaging (MRI) showed characteristic features of renal hemosiderosis. The patient was stabilized with temporary hemodialysis and intravenous fluid. The renal function fully recovered 3 weeks later. We review the literature and summarize the clinical features of this disease entity. To our knowledge, this case is the first to report such disorder with thorough investigation including concomitant diagnostic MRI imaging and renal biopsy.
一名阵发性夜间血红蛋白尿（PNH）中国患者发生急性非少尿性肾衰竭，并伴有尿路感染和溶血。无肾静脉血栓形成证据。肾活检显示急性肾小管坏死（ATN）和含铁血黄素沉着症特征。磁共振成像（MRI）显示肾含铁血黄素沉着症的特征性表现。患者通过临时血液透析和静脉补液病情稳定。3周后肾功能完全恢复。我们回顾文献并总结了该疾病实体的临床特征。据我们所知，该病例是首例对这种疾病进行包括同步诊断性MRI成像和肾活检在内的全面调查后报告的病例。
