干扰素诱导蛋白10、γ干扰素诱导的单核因子以及干扰素诱导的T细胞α趋化因子由胸腺上皮细胞产生，并吸引人类胸腺中的T细胞受体（TCR）αβ⁺ CD8⁺单阳性T细胞、TCRγδ⁺ T细胞和自然杀伤样细胞。
Interferon-inducible protein 10, monokine induced by interferon gamma, and interferon-inducible T-cell alpha chemoattractant are produced by thymic epithelial cells and attract T-cell receptor (TCR) alphabeta+ CD8+ single-positive T cells, TCRgammadelta+ T cells, and natural killer-type cells in human thymus.
作者信息
Romagnani P, Annunziato F, Lazzeri E, Cosmi L, Beltrame C, Lasagni L, Galli G, Francalanci M, Manetti R, Marra F, Vanini V, Maggi E, Romagnani S
机构信息
Department of Physiopathology, Endocrinology Unit, and the Department of Internal Medicine, University of Florence, Florence, Italy.
出版信息
Blood. 2001 Feb 1;97(3):601-7. doi: 10.1182/blood.v97.3.601.
Strong reactivity for interferon-inducible protein 10 (IP-10), monokine induced by interferon gamma (Mig), and interferon-inducible T-cell alpha chemoattractant (I-TAC) was found in epithelial cells mainly localized to the medulla of postnatal human thymus. The CXC chemokine receptor common to the 3 chemokines (CXCR3) was also preferentially expressed in medullary areas of the same thymuses and appeared to be a property of 4 distinct populations: CD3+ T-cell receptor (TCR) alphabeta+ CD8+ single-positive (SP) T cells, TCRgammadelta+ T cells, natural killer (NK)-type cells, and a small subset of CD3+(low) CD4+ CD8+ TCRalphabeta+ double-positive (DP) T cells. IP-10, Mig, and I-TAC showed chemoattractant activity for TCRalphabeta+ CD8+ SP T cells, TCRgammadelta+ T cells, and NK-type cells, suggesting their role in the migration of different subsets of mature thymocytes during human thymus lymphopoiesis.
在主要定位于出生后人胸腺髓质的上皮细胞中发现了对干扰素诱导蛋白10（IP - 10）、γ干扰素诱导的单核因子（Mig）和干扰素诱导的T细胞α趋化因子（I - TAC）的强反应性。这三种趋化因子共有的CXC趋化因子受体（CXCR3）也在同一胸腺的髓质区域优先表达，并且似乎是4个不同细胞群体的特性：CD3⁺T细胞受体（TCR）αβ⁺CD8⁺单阳性（SP）T细胞、TCRγδ⁺T细胞、自然杀伤（NK）型细胞以及一小部分CD3⁺（低）CD4⁺CD8⁺TCRαβ⁺双阳性（DP）T细胞。IP - 10、Mig和I - TAC对TCRαβ⁺CD8⁺SP T细胞、TCRγδ⁺T细胞和NK型细胞表现出趋化活性，表明它们在人类胸腺淋巴细胞生成过程中不同亚群成熟胸腺细胞的迁移中发挥作用。
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