Merrow M, Franchi L, Dragovic Z, Görl M, Johnson J, Brunner M, Macino G, Roenneberg T
Institute for Medical Psychology, University of Munich, D-80336 Munich, Germany.
EMBO J. 2001 Feb 1;20(3):307-15. doi: 10.1093/emboj/20.3.307.
FREQUENCY (FRQ) is a critical element of the circadian system of Neurospora. The white collar genes are important both for light reception and circadian function. We show that the responsiveness of the light input pathway is circadianly regulated. This circadian modulation extends to light-inducible components and functions that are not rhythmic themselves in constant conditions. FRQ interacts genetically and physically with WHITE COLLAR-1, and physically with WHITE COLLAR-2. These findings begin to address how components of the circadian system interact with basic cellular functions, in this case with sensory transduction.
频率(FRQ)是粗糙脉孢菌昼夜节律系统的关键要素。白领基因对于光接收和昼夜节律功能都很重要。我们发现光输入途径的反应性受昼夜节律调节。这种昼夜节律调节延伸到在恒定条件下本身没有节律的光诱导成分和功能。FRQ在遗传和物理层面上与白领-1相互作用,并在物理层面上与白领-2相互作用。这些发现开始揭示昼夜节律系统的组成部分如何与基本细胞功能相互作用,在这种情况下是与感觉转导相互作用。