酰基-酰基载体蛋白对大肠杆菌乙酰辅酶A羧化酶的抑制作用。
Inhibition of Escherichia coli acetyl coenzyme A carboxylase by acyl-acyl carrier protein.
作者信息
Davis M S, Cronan J E
机构信息
Department of Microbiology, University of Illinois, Urbana, Illinois 61801, USA.
出版信息
J Bacteriol. 2001 Feb;183(4):1499-503. doi: 10.1128/JB.183.4.1499-1503.2001.
Abstract
Escherichia coli acetyl coenzyme A carboxylase (ACC), the first enzyme of the fatty acid biosynthetic pathway, is inhibited by acylated derivatives of acyl carrier protein (ACP). ACP lacking an acyl moiety does not inhibit ACC. Acylated derivatives of ACP having chain lengths of 6 to 20 carbon atoms were similarly inhibitory at physiologically relevant concentrations. The observed feedback inhibition was specific to the protein moiety, as shown by the inability of the palmitoyl thioester of spinach ACP I to inhibit ACC.
摘要
大肠杆菌乙酰辅酶A羧化酶（ACC）是脂肪酸生物合成途径中的首个酶，它受到酰基载体蛋白（ACP）的酰化衍生物的抑制。缺乏酰基部分的ACP不会抑制ACC。链长为6至20个碳原子的ACP酰化衍生物在生理相关浓度下同样具有抑制作用。观察到的反馈抑制作用对蛋白质部分具有特异性，这一点通过菠菜ACP I的棕榈酰硫酯无法抑制ACC得以证明。
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