Patel R, Rouse M S, Piper K E, Steckelberg J M
Division of Infectious Diseases and Infectious Diseases Research Laboratory, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA.
Antimicrob Agents Chemother. 2001 Feb;45(2):621-3. doi: 10.1128/AAC.45.2.621-623.2001.
We compared the activities of linezolid (25 mg/kg of body weight, administered intraperitoneally every 8 h) and of vancomycin (25 mg/kg of body weight, administered intraperitoneally every 8 h) in a rat model of vanA vancomycin-resistant Enterococcus faecium experimental endocarditis. Results were expressed as median log(10) CFU per gram of vegetation after 3 days of treatment. The median log(10) CFU per gram of vegetation was 10.1 among 7 untreated control animals, 10.2 among 9 vancomycin-treated animals, and 7.9 among 10 linezolid-treated animals. Linezolid treatment was more active (P < 0.05) than vancomycin treatment or no treatment.
我们在vanA耐万古霉素屎肠球菌实验性心内膜炎的大鼠模型中,比较了利奈唑胺(25mg/kg体重,每8小时腹腔注射一次)和万古霉素(25mg/kg体重,每8小时腹腔注射一次)的活性。结果以治疗3天后每克赘生物的中位log(10)CFU表示。7只未治疗的对照动物每克赘生物的中位log(10)CFU为10.1,9只接受万古霉素治疗的动物为10.2,10只接受利奈唑胺治疗的动物为7.9。利奈唑胺治疗比万古霉素治疗或不治疗更有效(P<0.05)。