Zee D S, Robinson D A
Ann Neurol. 1979 May;5(5):405-14. doi: 10.1002/ana.410050502.
Eye movements in a patient with saccadic oscillations (ocular flutter) were recorded and analyzed. Findings were related to recent microelectrode studies in the monkey pontine reticular formation which have identified three types of premotor neurons related to saccadic eye movements: burst, tonic, and pause cells. We incorporated these cell types into a hypothetical circuit that generates saccades by rapidly driving the eye to a designated orbital position rather than preprogramming a distance for movement. Physiological measurements suggest that this neural network is unstable and that the burst neurons must be tonically inhibited to prevent saccadic oscillations during periods of fixation. Pause cells, which discharge tonically except during saccades, when they pause, appear to inhibit burst cells and prevent such saccadic oscillations. Analysis of our patient's behavior indicates that many types of saccadic oscillations can be explained and classified by assuming an abnormality of pause cell control over saccadic burst neurons.
对一名患有眼球跳动性振荡（眼扑动）患者的眼球运动进行了记录和分析。研究结果与近期对猴脑桥网状结构的微电极研究相关，该研究已确定了三种与眼球跳动性眼动相关的运动前神经元类型：爆发型、紧张型和暂停型细胞。我们将这些细胞类型纳入一个假设的回路中，该回路通过快速将眼睛驱动到指定的眼眶位置来产生扫视，而不是预先设定一个移动距离。生理测量表明，这个神经网络是不稳定的，爆发型神经元必须受到紧张性抑制，以防止在注视期间出现眼球跳动性振荡。暂停型细胞在扫视期间除外会持续放电，当它们暂停时，似乎会抑制爆发型细胞并防止此类眼球跳动性振荡。对我们患者行为的分析表明，通过假设暂停型细胞对眼球跳动爆发型神经元的控制异常，可以解释和分类多种类型的眼球跳动性振荡。
