Hain T C, Zee D S, Mordes M
Ann Neurol. 1986 Mar;19(3):299-301. doi: 10.1002/ana.410190315.
A patient with a neurodegenerative disease had abnormal saccades only when he blinked. These saccades were hypermetric and were followed immediately, without any intersaccadic interval, by a large, oppositely directed saccade (dynamic overshoot). To explain these findings, we hypothesize that a blink-related neural signal can modulate the activity of pause cells that normally inhibit saccadic burst neurons during fixation. In pathological circumstances, abnormal function of pause cells could lead to large-amplitude saccadic oscillations. In normal subjects, blinks could induce short bursts of low-amplitude flutter.
一名患有神经退行性疾病的患者仅在眨眼时出现异常扫视。这些扫视幅度过大，并且在没有任何扫视间隔的情况下，紧接着会出现一个大幅度的、方向相反的扫视（动态过冲）。为了解释这些发现，我们推测与眨眼相关的神经信号可以调节暂停细胞的活动，这些暂停细胞在注视期间通常会抑制扫视爆发神经元。在病理情况下，暂停细胞的异常功能可能导致大幅度的扫视振荡。在正常受试者中，眨眼可能会诱发短时间的低幅度颤动爆发。
