重温多格浅滩瘙痒症：从海洋海绵近似奇异海绵（Theonella aff. mirabilis）中分离出具有细胞毒性的成分氯化（2-羟乙基）二甲基锍。

Dogger Bank Itch revisited: isolation of (2-hydroxyethyl) dimethylsulfoxonium chloride as a cytotoxic constituent from the marine sponge Theonella aff. mirabilis.

作者信息

Warabi K, Nakao Y, Matsunaga S, Fukuyama T, Kan T, Yokoshima S, Fusetani N

机构信息

Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, 113-8657, Tokyo, Japan.

出版信息

Comp Biochem Physiol B Biochem Mol Biol. 2001 Jan;128(1):27-30. doi: 10.1016/s1096-4959(00)00316-x.

DOI:10.1016/s1096-4959(00)00316-x

PMID:11163301

Abstract

(2-Hydroxyethyl) dimethylsulfoxonium chloride (1), the well-known causative agent of Dogger Bank Itch, has been isolated as a cytotoxic constituent from the marine sponge Theonella aff. mirabilis. The structure of 1 was determined by spectral and X-ray crystallographic analyses.

摘要

（2-羟乙基）二甲基氯化锍（1）是已知的多格浅滩瘙痒病的病原体，已从海洋海绵近似奇异海绵（Theonella aff. mirabilis）中分离出作为一种细胞毒性成分。通过光谱分析和X射线晶体学分析确定了1的结构。