来自海洋海绵圆柱软海绵的具有抗真菌和细胞毒性的缩肽类化合物A-C
Halicylindramides A-C, antifungal and cytotoxic depsipeptides from the marine sponge Halichondria cylindrata.
作者信息
Li H Y, Matsunaga S, Fusetani N
机构信息
Laboratory of Marine Biochemistry, Faculty of Agriculture, University of Tokyo, Japan.
出版信息
J Med Chem. 1995 Jan 20;38(2):338-43. doi: 10.1021/jm00002a015.
Halicylindramides A-C (1-3) have been isolated from the Japanese marine sponge Halichondria cylindrata. They are tetradecapeptides with the N-terminus blocked by a formyl group and the C-terminus lactonized with a threonine residue. Their total structures including absolute stereochemistry were determined by a combination of spectral and chemical methods. Halicylindramides A-C were antifungal against Mortierella ramanniana and cytotoxic against P388 murine leukemia cells.
从日本海洋海绵柱形软海绵（Halichondria cylindrata）中分离出了柱形海鞘酰胺A - C（1 - 3）。它们是十四肽，N端被一个甲酰基封闭，C端与一个苏氨酸残基形成内酯。通过光谱和化学方法相结合确定了它们包括绝对立体化学的完整结构。柱形海鞘酰胺A - C对拉曼被孢霉（Mortierella ramanniana）具有抗真菌活性，对P388小鼠白血病细胞具有细胞毒性。
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