Elwyn D H, Kinney J M, Jeevanandam M, Gump F E, Broell J R
Ann Surg. 1979 Jul;190(1):117-27. doi: 10.1097/00000658-197907000-00023.
The metabolic and hormonal effect of glucose loads, ranging from 125 to 504 g/70 kg/day, were studied in severely injured patients. There was little or no correlation of glucose intake with nitrogen balance, plasma glucose, fatty acid concentrations, or epinephrine excretion. Increased norepinephrine excretion correlated with and may have resulted from increased glucose intake. Serum glucagon concentrations averaged 320 pg/ml and were not depressed by glucose intake. Insulin concentrations rose with glucose intake but were low for the level of plasma glucose. Glucose oxidation and non-oxidative metabolism, including glycogen deposition, correlated well with glucose intake. Gluconeogenesis from alanine was much higher than normal but was completely suppressed at very high intakes. The data imply that cycling of glucose, with glycerol, glycogen, or both, increased with increasing glucose intake.
对严重受伤患者研究了葡萄糖负荷量为125至504克/70千克/天范围时的代谢和激素效应。葡萄糖摄入量与氮平衡、血浆葡萄糖、脂肪酸浓度或肾上腺素排泄量之间几乎没有或没有相关性。去甲肾上腺素排泄量增加与葡萄糖摄入量增加相关，且可能由葡萄糖摄入量增加导致。血清胰高血糖素浓度平均为320皮克/毫升，且未因葡萄糖摄入而降低。胰岛素浓度随葡萄糖摄入而升高，但相对于血浆葡萄糖水平较低。葡萄糖氧化和非氧化代谢，包括糖原沉积，与葡萄糖摄入量密切相关。丙氨酸的糖异生比正常情况高得多，但在非常高的摄入量时被完全抑制。数据表明，葡萄糖与甘油、糖原或两者的循环随着葡萄糖摄入量的增加而增加。
