从第7外显子序列解析黑猩猩ABO血型基因的基因多样性。

Gene diversity of chimpanzee ABO blood group genes elucidated from exon 7 sequences.

作者信息

Sumiyama K, Kitano T, Noda R, Ferrell R E, Saitou N

机构信息

Laboratory of Evolutionary Genetics, National Institute of Genetics, Mishima 411-8540, Japan.

出版信息

Gene. 2000 Dec 23;259(1-2):75-9. doi: 10.1016/s0378-1119(00)00440-6.

DOI:10.1016/s0378-1119(00)00440-6

PMID:11163964

Abstract

Human and non-human primate ABO blood group genes show relatively large numbers of nucleotide differences. In this study, we determined exon 7 sequences for 10 individuals of common chimpanzee and for four individuals of bonobo to estimate nucleotide diversities among them. Sequence data showed the existence of chimpanzee specific 9-base deletion in the beginning of the exon 7 coding region. From a phylogenetic network of exon 7 sequences of ABO blood group genes for human, common chimpanzee, bonobo and gorilla, effects of parallel substitutions and/or some kinds of convergent events are inferred in the chimpanzee lineage. We also estimated nucleotide diversities for common chimpanzee and bonobo ABO blood group genes, and these values were 0.4% and 0.2%, respectively. These values are higher than that of most human genes.

摘要

人类和非人类灵长类动物的ABO血型基因显示出相对大量的核苷酸差异。在本研究中，我们测定了10只普通黑猩猩个体和4只倭黑猩猩个体的外显子7序列，以估计它们之间的核苷酸多样性。序列数据显示在第7外显子编码区起始处存在黑猩猩特有的9个碱基的缺失。从人类、普通黑猩猩、倭黑猩猩和大猩猩ABO血型基因外显子7序列的系统发育网络中，可以推断出在黑猩猩谱系中存在平行替换和/或某种趋同事件的影响。我们还估计了普通黑猩猩和倭黑猩猩ABO血型基因的核苷酸多样性，这些值分别为0.4%和0.2%。这些值高于大多数人类基因的值。