Rao Y, Xiao P, Xu S
Institute of Senile Encephalopathy, The Second School of Medicine, Guangzhou University of Traditional Chinese Medicine, 510405, PR, Guangzhou, China.
Neurosci Lett. 2001 Feb 9;298(3):183-6. doi: 10.1016/s0304-3940(00)01744-4.
Effects of intrahippocampal treatment of aniracetam, a selective agonist for DL-alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproionic acid (AMPA) receptors, on Y-maze avoidance learning task and behavioral long-term potentiation (LTP) in perforant path-dentate gyrus were studied in freely moving rats by using in vivo electrophysiology combined with behavioral tests. The results were as follows: (1) intrahippocampal treatment of aniracetam reversibly enhanced basal synaptic transmission in perforant path to dentate gyrus in a dosage dependent manner; (2) aniracetam produced improvement in Y-maze learning performance when administration occurred 5 min prior to maze learning; (3) aniracetam administration significantly facilitated behavioral LTP in dentate gyrus, while the maximal amplitude of LTP has no significant difference when compared to saline group. The present results indicate that hippocampal AMPA receptors are involved in learning and memory.
通过体内电生理学与行为测试相结合的方法，在自由活动的大鼠中研究了海马内注射氨己烯酸（一种DL-α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）受体的选择性激动剂）对Y迷宫回避学习任务和穿通通路-齿状回行为性长时程增强（LTP）的影响。结果如下：（1）海马内注射氨己烯酸以剂量依赖性方式可逆性增强从穿通通路到齿状回的基础突触传递；（2）在迷宫学习前5分钟给药时，氨己烯酸可改善Y迷宫学习表现；（3）给予氨己烯酸显著促进齿状回的行为性LTP，而LTP的最大幅度与生理盐水组相比无显著差异。目前的结果表明海马AMPA受体参与学习和记忆。
