Apelo R, Veloso I
Fertil Steril. 1975 Mar;26(3):283-8. doi: 10.1016/s0015-0282(16)40998-2.
One hundred eighty-one women received 30 mug of ethinyl estradiol plus 150 mug of d-norgestrel as an oral contraceptive for 21 days and then received no tablets for the next seven days for a total of 1,488 cycles. There were no pregnancies. Cycle control was good to excellent. Menstrual cycles lasted 25 to 32 days in 96.2% of treatment cycles. Menstruation lasted three to five days in 93.2% of the cycles, and it began three to five days after the last day of medication in 79.1%. The menstrual flow was moderate in 87%. Breakthrough bleeding occurred in 2.0% of treatment cycles, spotting in 0.1%, and amenorrhea in 0.8%. The incidence of adverse subjective symptoms was minimal and significant increases compared with the pretreatment cycle were noted only for nausea in the first two cycles and for nervousness in the second cycle of treatment. Overall incidence of nausea was 3.2% of treatment cycles.
181名女性服用含30微克炔雌醇加150微克左炔诺孕酮的口服避孕药，连续服用21天，然后停药7天，共计1488个周期。无一例妊娠。月经周期控制良好至极佳。96.2%的治疗周期中月经周期持续25至32天。93.2%的周期中月经持续3至5天，79.1%的周期中月经在停药后3至5天开始。87%的月经量适中。2.0%的治疗周期出现突破性出血，0.1%出现点滴出血，0.8%出现闭经。不良主观症状的发生率极低，仅在前两个周期中恶心以及治疗的第二个周期中紧张与治疗前周期相比有显著增加。恶心的总体发生率为治疗周期的3.2%。
