Vazquez-Torres A, Fang F C
Department of Medicine, University of Colorado Health Sciences Center, 4200 E. 9th Ave, B168, Denver, CO 80262, USA.
Trends Microbiol. 2001 Jan;9(1):29-33. doi: 10.1016/s0966-842x(00)01897-7.
Numerous observations have established a crucial role for phagocytic cells in host resistance to Salmonella. Activated macrophages rely on a complex array of oxygen-dependent antimicrobial molecules to inhibit or kill intracellular Salmonella. An initial oxidative bactericidal phase, which is dependent on the respiratory burst phagocyte oxidase (phox) is succeeded by a prolonged nitrosative bacteriostatic phase, which is dependent on inducible nitric oxide synthase (iNOS). The sequential contribution of phox and iNOS to anti-Salmonella innate immunity has been demonstrated both in vitro and in vivo. The temporal progression from the predominant production of reactive oxygen species to the production of nitrogen oxides could optimize the initial reduction in microbial burden while minimizing the immunopathological consequences of the host inflammatory response.
大量观察结果已证实吞噬细胞在宿主抵抗沙门氏菌方面起着关键作用。活化的巨噬细胞依靠一系列复杂的氧依赖性抗菌分子来抑制或杀死细胞内的沙门氏菌。最初的氧化杀菌阶段依赖于呼吸爆发吞噬细胞氧化酶（phox），随后是一个延长的亚硝化抑菌阶段，该阶段依赖于诱导型一氧化氮合酶（iNOS）。phox和iNOS对沙门氏菌先天免疫的相继作用已在体外和体内得到证实。从主要产生活性氧到产生氮氧化物的时间进程可以优化微生物负荷的初始降低，同时将宿主炎症反应的免疫病理后果降至最低。
