Biomedical Research Group, ICBS, "Campus Universitário do Araguaia", Federal University of Mato Grosso (UFMT), Rodovia MT100, Km 3, 5, 78698-000, Pontal do Araguaia, Brazil.
Arch Immunol Ther Exp (Warsz). 2011 Dec;59(6):441-8. doi: 10.1007/s00005-011-0144-z. Epub 2011 Oct 5.
Although oxygen, nitrogen, and chlorine reactive species have been associated with disease pathogenesis, their partial absence is very harmful to the body's innate immune defense. Lacking of adequate release of free radicals from activated phagocytes is related to impaired ability on fungi, bacteria, and protozoa killing. We constructed an updated conceptual landmark regarding the paramount role of free radicals in phagocyte defense systems (phagocyte oxidase, myeloperoxidase, and nitric oxide/peroxynitrite system) on natural immunity. Diverse fungal, bacterial and protozoal pathogens evade the phagocytes' oxidative/nitrosative burst though antioxidant genes, enzymes and proteins. The most important evasion mechanisms were also described and discussed. These interconnected systems were reviewed and discussed on the basis of knowledge from relevant research groups around the globe. Phagocyte-derived free radicals are essential to destroy important human pathogens during the course of innate immunity.
尽管氧气、氮气和氯气反应性物质与疾病发病机制有关，但它们的部分缺乏对身体的先天免疫防御非常有害。活性吞噬细胞中自由基的释放不足与真菌、细菌和原生动物杀伤能力受损有关。我们构建了一个关于自由基在吞噬细胞防御系统（吞噬细胞氧化酶、髓过氧化物酶和一氧化氮/过氧亚硝酸盐系统）在天然免疫中的主要作用的最新概念性里程碑。不同的真菌、细菌和原生动物病原体通过抗氧化基因、酶和蛋白质逃避吞噬细胞的氧化/硝化爆发。还描述和讨论了最重要的逃避机制。根据来自全球相关研究小组的知识，对这些相互关联的系统进行了综述和讨论。吞噬细胞衍生的自由基对于在先天免疫过程中破坏重要的人类病原体是必不可少的。
