褪黑素通过大鼠视交叉上核切片培养中的MT(2)受体抑制精氨酸加压素释放。

Melatonin inhibits Arg-vasopressin release via MT(2) receptor in the suprachiasmatic nucleus-slice culture of rats.

作者信息

Isobe Y, Torii T, Nishino H

机构信息

Department of Physiology, Nagoya City University Medical School, Mizuho-ku, 467-8601, Nagoya, Japan.

出版信息

Brain Res. 2001 Jan 19;889(1-2):214-9. doi: 10.1016/s0006-8993(00)03139-5.

DOI:10.1016/s0006-8993(00)03139-5

PMID:11166706

Abstract

The effect of melatonin on the release of Arg-vasopressin (AVP) was analyzed in a suprachiasmatic nucleus-slice explant culture. The release of AVP into the culture medium exhibited a circadian rhythm, with higher level during the subjective day and lower level during the subjective night. Melatonin (500 nM) inhibited the release of AVP. Luzindole, a MT(2) (Mel 1b) melatonin receptor antagonist, attenuated the effect of melatonin on the AVP release. Results indicate that the inhibition of AVP release by melatonin in the suprachiasmatic nucleus-slice culture depends at least in part on the melatonin MT(2) receptor.

摘要

在视交叉上核切片外植体培养中分析了褪黑素对精氨酸加压素（AVP）释放的影响。AVP向培养基中的释放呈现昼夜节律，在主观白天水平较高，在主观夜间水平较低。褪黑素（500 nM）抑制了AVP的释放。MT（2）（Mel 1b）褪黑素受体拮抗剂鲁辛朵减弱了褪黑素对AVP释放的作用。结果表明，视交叉上核切片培养中褪黑素对AVP释放的抑制作用至少部分依赖于褪黑素MT（2）受体。