通过酵母功能基因组学迈向真正的整合生物学。

Towards a truly integrative biology through the functional genomics of yeast.

作者信息

Delneri D, Brancia F L, Oliver S G

机构信息

School of Biological Science, University of Manchester, 2.205 Stopford Building, Manchester Oxford Road, M13 9PT, UK.

出版信息

Curr Opin Biotechnol. 2001 Feb;12(1):87-91. doi: 10.1016/s0958-1669(00)00179-8.

DOI:10.1016/s0958-1669(00)00179-8

PMID:11167079

Abstract

A complete library of mutant Saccharomyces cerevisiae strains, each deleted for a single representative of yeast's 6000 protein-encoding genes, has been constructed. This represents a major biological resource for the study of eukaryotic functional genomics. However, yeast is also being used as a test-bed for the development of functional genomic technologies at all levels of analysis, including the transcriptome, proteome and metabolome.

摘要

已经构建了一个完整的酿酒酵母突变体菌株文库，其中每个菌株都缺失了酵母6000个蛋白质编码基因中的一个代表性基因。这是研究真核生物功能基因组学的一项重要生物学资源。然而，酵母也正被用作一个试验平台，用于开发各级分析水平的功能基因组技术，包括转录组学、蛋白质组学和代谢组学。