Mewes H W, Albermann K, Bähr M, Frishman D, Gleissner A, Hani J, Heumann K, Kleine K, Maierl A, Oliver S G, Pfeiffer F, Zollner A
Max-Planck-Institut für Biochemie, Martinsried, Germany.
Nature. 1997 May 29;387(6632 Suppl):7-65. doi: 10.1038/42755.
The collaboration of more than 600 scientists from over 100 laboratories to sequence the Saccharomyces cerevisiae genome was the largest decentralised experiment in modern molecular biology and resulted in a unique data resource representing the first complete set of genes from a eukaryotic organism. 12 million bases were sequenced in a truly international effort involving European, US, Canadian and Japanese laboratories. While the yeast genome represents only a small fraction of the information in today's public sequence databases, the complete, ordered and non-redundant sequence provides an invaluable resource for the detailed analysis of cellular gene function and genome architecture. In terms of throughput, completeness and information content, yeast has always been the lead eukaryotic organism in genomics; it is still the largest genome to be completely sequenced.
来自100多个实验室的600多名科学家合作对酿酒酵母基因组进行测序，这是现代分子生物学中规模最大的分散式实验，产生了一个独特的数据资源，代表了来自真核生物的第一套完整基因。在一项真正的国际合作中，欧洲、美国、加拿大和日本的实验室对1200万个碱基进行了测序。虽然酵母基因组只占当今公共序列数据库中信息的一小部分，但完整、有序且无冗余的序列为细胞基因功能和基因组结构的详细分析提供了宝贵资源。在通量、完整性和信息含量方面，酵母一直是基因组学领域的领先真核生物；它仍是已完成全测序的最大基因组。
