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一种强效干扰素诱导剂对急性和慢性乳酸脱氢酶病毒血症的影响。

Effect of a potent interferon inducer on acute and chronic lactic dehydrogenase virus viremia.

作者信息

Johnson M L, duBuy H G

出版信息

Infect Immun. 1975 Jan;11(1):113-6. doi: 10.1128/iai.11.1.113-116.1975.

DOI:10.1128/iai.11.1.113-116.1975
PMID:1116871
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC415033/
Abstract

The effect of a single and multiple doses of polyinosinic-polycytidylic acid (poly (I). poly(C) on lactic dehydrogenase virus viremia has been studied. A single injection of 200 mug of poly (I)-poly(C) given 6 h before infection with lactic dehydrogenase virus caused a temporary decrease in viremia of about 2.5 log10. Repeated injections of 100 mug of poly(I)-poly(C) every 24 h beginning at -24 h caused a temporary decrease in viremia of about 4.0 log 10. Therapeutic treatment with optimal dosage schedules (100 mug every 24 h) caused a reduction in viremia of 1.0 to 2.0 log10. This decrease lasted for at least 24 h after the treatment was stopped. Some possible reasons for the limited effectiveness of poly (I)-poly(C) in this system are discussed.

摘要

研究了单剂量和多剂量的聚肌苷酸-聚胞苷酸（聚（I）-聚（C））对乳酸脱氢酶病毒血症的影响。在感染乳酸脱氢酶病毒前6小时单次注射200微克聚（I）-聚（C），可使病毒血症暂时降低约2.5个对数10。从-24小时开始每24小时重复注射100微克聚（I）-聚（C），可使病毒血症暂时降低约4.0个对数10。采用最佳剂量方案（每24小时100微克）进行治疗，可使病毒血症降低1.0至2.0个对数10。这种降低在停止治疗后至少持续24小时。文中讨论了聚（I）-聚（C）在该系统中效果有限的一些可能原因。

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本文引用的文献

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RELATIONSHIP OF INTERFERON PRODUCTION TO VIRUS GROWTH IN VIVO.体内干扰素产生与病毒生长的关系。
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Studies on the multiplication and the properties of the lactic dehydrogenase agent.乳酸脱氢酶制剂的增殖及其特性研究。
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Adaptation of orbital bleeding technic to rapid serial blood studies.眼眶出血技术在快速系列血液研究中的应用。
Proc Soc Exp Biol Med. 1960 Aug-Sep;104:751-4. doi: 10.3181/00379727-104-25975.
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Infectious virus-antibody complex in the blood of chronically infected mice.慢性感染小鼠血液中的传染性病毒-抗体复合物。
J Exp Med. 1966 Jul 1;124(1):81-97. doi: 10.1084/jem.124.1.81.
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Studies on the mechanism of action of Riley virus. 3. Replication of Riley's plasma enzyme-elevating virus in vitro.莱利病毒作用机制的研究。3. 莱利血浆酶升高病毒的体外复制。
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6
Some properties of the lactic dehydrogenase agent of mice.小鼠乳酸脱氢酶制剂的某些特性。
J Exp Med. 1965 Sep 1;122(3):587-600. doi: 10.1084/jem.122.3.587.
7
Kinetics of serum interferon response in mice after single and multiple injections of polyI-poly C.
Proc Soc Exp Biol Med. 1971 Feb;136(2):394-8. doi: 10.3181/00379727-136-35272.
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Late therapy with an interferon stimulator in an arbovirus encephalitis in mice.在小鼠虫媒病毒脑炎中使用干扰素刺激剂进行晚期治疗。
Proc Soc Exp Biol Med. 1971 Jan;136(1):323-7. doi: 10.3181/00379727-136-35257.
9
Effect of statolon on lactate dehydrogenase virus infection in mice.杀稻瘟菌素对小鼠乳酸脱氢酶病毒感染的影响。
Arch Gesamte Virusforsch. 1970;31(3):191-5. doi: 10.1007/BF01253751.
10
Relationship between dose size and dose interval of polyinosinic polycytidylic acid and interferon hyporesponsiveness in mice.小鼠中聚肌苷酸-聚胞苷酸的剂量大小与剂量间隔和干扰素低反应性之间的关系
Proc Soc Exp Biol Med. 1970 Nov;135(2):340-4. doi: 10.3181/00379727-135-35047.

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