Oh J O, O'Connor G R
Infect Immun. 1971 Oct;4(4):407-10. doi: 10.1128/iai.4.4.407-410.1971.
A potent interferon inducer, synthetic polyinosinic acid-polycytidylic acid complex (poly I:C), was used prophylactically and therapeutically in experimental ocular Toxoplasma infections in rabbits. Daily intravenous injections of poly I:C alone or when combined with daily subconjunctival injections of the inducer delayed the appearance of conjunctivitis, corneal opacity, and iritis in Toxoplasma-infected eyes provided that the treatment was started 1 day before the infection. When the treatment was begun at the same time or 1 day after the infection, no delay in the production of the ocular lesions was noted. In no case was the treatment curative or completely suppressive.
一种强效干扰素诱导剂，合成聚肌苷酸-聚胞苷酸复合物（聚肌胞苷酸），被用于兔实验性眼部弓形虫感染的预防和治疗。单独每日静脉注射聚肌胞苷酸，或与每日结膜下注射诱导剂联合使用时，只要在感染前1天开始治疗，就能延缓弓形虫感染眼结膜炎、角膜混浊和虹膜炎的出现。当在感染同时或感染后1天开始治疗时，未观察到眼部病变产生的延迟。在任何情况下，该治疗都不是治愈性的或完全抑制性的。
