Tsuruta D, Kono T, Kutsuna H, Yashiro N, Ishii M
Department of Dermatology, Osaka City University Medical School, Japan.
J Cutan Pathol. 2001 Jan;28(1):44-8. doi: 10.1034/j.1600-0560.2001.280105.x.
Granulomatous slack skin is a rare lymphoproliferative disorder characterized clinically by gradual development of pendulous folds of lax erythematous skin in flexural areas, and histologically by non-necrotizing granuloma, with numerous multinucleated giant cells, mononuclear histiocytes, and atypical lymphocytes associated with loss of elastic fibers. Although there are many reports describing the histological and immunophenotypic features of this disease, only a few have described the ultrastructural features.
Here we report a case of granulomatous slack skin and describe the ultrastructural findings.
We could detect some previously not noted abnormal findings in multinucleated giant cells, histiocytes, and atypical lymphocytes.
肉芽肿性皮肤松弛症是一种罕见的淋巴增殖性疾病，临床特征为屈侧部位逐渐出现松弛红斑皮肤的下垂褶皱，组织学特征为非坏死性肉芽肿，伴有大量多核巨细胞、单核组织细胞和与弹性纤维缺失相关的非典型淋巴细胞。尽管有许多报告描述了该疾病的组织学和免疫表型特征，但仅有少数报告描述了其超微结构特征。
在此，我们报告一例肉芽肿性皮肤松弛症病例并描述其超微结构发现。
我们在多核巨细胞、组织细胞和非典型淋巴细胞中检测到一些先前未被注意到的异常发现。
