Horton Y M, Johnson P R
University of Edinburgh, Leukaemia Research Fund, John Hughes Bennett Laboratory, Department of Oncology, Edinburgh, UK.
Cancer Genet Cytogenet. 2001 Jan 15;124(2):172-4. doi: 10.1016/s0165-4608(00)00345-9.
To our knowledge, 58 cases of trisomy 14 in association with hematological malignancies have been reported, predominantly in myeloid malignancies. We report two patients with trisomy 14 associated with myelodysplasia. The bone marrow showed trilineage dysplasia, monocytosis and only mild thrombocytopenia. A nonmosaic karyotype was seen in both patients and survival from diagnosis was short (<1 year). The features are consistent with data from other published cases and support the hypothesis that trisomy 14 is a non-random karyotypic abnormality, with defined clinical associations and a poor prognosis.
据我们所知，已有58例14三体综合征合并血液系统恶性肿瘤的病例报道，主要为髓系恶性肿瘤。我们报告了2例14三体综合征合并骨髓增生异常综合征的患者。骨髓显示三系发育异常、单核细胞增多，仅有轻度血小板减少。两名患者均可见非嵌合核型，从诊断开始的生存期较短（<1年）。这些特征与其他已发表病例的数据一致，并支持以下假设：14三体是一种非随机的核型异常，具有明确的临床关联且预后不良。
