Tótth Á Árpád, Schnur János, Ladányi Andrea, Kopper László
Semmelweis University of Medicine, 1st Institute of Pathology and Experimental Cancer Research, Budapest, Hungary.
Pathol Oncol Res. 1996;2(3):174-176. doi: 10.1007/BF02903522.
Primary central nervous system lymphomas are rather rare, however, their frequency seems to be increasing in both high risk and immunocompetent patients with very poor prognosis. Here we describe a model intracerebrally xenotransplating human non Hodgkin lymphoma cells of B cell origin (HT 58). This offers a unique possibility to study the theraputic response, especially on systemic treatment. Briefly, one million lymphoma cells grew as meningeal tumor mass, infiltrating the brain directly as well as via the perivascular space. The lymphoma cells preserved all the phenotypic characteristics of the source tumor.
原发性中枢神经系统淋巴瘤相当罕见，然而，在高危和免疫功能正常但预后极差的患者中，其发病率似乎在上升。在此，我们描述了一种将B细胞源性人类非霍奇金淋巴瘤细胞（HT 58）脑内异种移植的模型。这为研究治疗反应，尤其是全身治疗反应提供了独特的可能性。简而言之，一百万个淋巴瘤细胞生长为脑膜肿瘤块，直接浸润大脑并通过血管周围间隙浸润。淋巴瘤细胞保留了原发肿瘤的所有表型特征。
