Bergmann M, Kuchelmeister K, Edel G, Heinecke A
Institut of Neuropathology, University of Münster, Germany.
Zentralbl Pathol. 1993 Mar;139(1):37-44.
Primary cerebral lymphomas (PCL) are rare tumors, which, however, occur at increasing frequency. From 1980 to 1991, 44 PCL were histologically diagnosed from immunocompetent patients in our department. According to the updated Kiel Classification, 13.5% of the tumors were of low malignancy (4 immunocytomas, 2 centroblastic-centrocytic), and 79.5% were highly malignant B-cell lymphomas (26 centroblastic, 2 Burkitt-type, 3 immunoblastic, 4 unclassified). Two T-cell lymphomas and one large-cell anaplastic lymphoma were found as well. A reactive tissue infiltrate consisting of varying amounts of small T-cells and tissue macrophages was present in all B-cell lymphomas. PCNA-indices reflected the histological grade, with mean counts of 19.5% in low grade neoplasms and 59.3% in high grade ones. No correlation was found to exist between PCNA-index and patient survival.
原发性脑淋巴瘤（PCL）是一种罕见的肿瘤，但其发病率呈上升趋势。1980年至1991年期间，我们科室从免疫功能正常的患者中经组织学诊断出44例PCL。根据最新的 Kiel 分类，13.5%的肿瘤为低恶性（4例免疫细胞瘤，2例中心母细胞 - 中心细胞型），79.5%为高恶性B细胞淋巴瘤（26例中心母细胞型，2例伯基特型，3例免疫母细胞型，4例未分类）。还发现了2例T细胞淋巴瘤和1例大细胞间变性淋巴瘤。在所有B细胞淋巴瘤中均存在由不同数量的小T细胞和组织巨噬细胞组成的反应性组织浸润。PCNA指数反映了组织学分级，低级别肿瘤的平均计数为19.5%，高级别肿瘤为59.3%。未发现PCNA指数与患者生存率之间存在相关性。
