囊性纤维化患者针对铜绿假单胞菌外毒素A抗原的IgG抗体的量及亲和力

Amount and Avidity of IgG Antibodies to Pseudomonas Aeruginosa Exotoxin A Antigen in Cystic Fibrosis Patients.

作者信息

Polanec Janja, Patzer Jan, Grzybowski Jacek, Strukelj Milan, Pavelic Zlatko P

机构信息

Institute of Microbiology, Ljubljana, Slovenia.

出版信息

Pathol Oncol Res. 1997;3(1):26-29. doi: 10.1007/BF02893348.

DOI:10.1007/BF02893348

PMID:11173620

Abstract

Amount and avidity of serum IgG antibodies to Pseudomonas aeruginosa exotoxin A in sera of 31 patients with cystic fibrosis (CF) was studied. Eight patients had P. aeruginosa isolated from the sputum on multiple occasions, while from 23 patients no P. aeruginosa was isolated. Amount of IgG antibodies to P. aeruginosa exotoxin A were significantly increased in the serum of patients with P. aeruginosa pulmonary colonization (p<0.0001). On the contrary, serum IgG avidity in the colonized and in the non-colonized CF patients was low (<10) and was statistically different when compared to the 30 age-matched healthy controls (p<0.0001). There was no change in IgG avidity in six chronically infected CF patients from whom we obtained serum samples after half a year period (p=0,55).

摘要

对31例囊性纤维化（CF）患者血清中抗铜绿假单胞菌外毒素A的血清IgG抗体量及亲和力进行了研究。8例患者多次从痰液中分离出铜绿假单胞菌，而23例患者未分离出铜绿假单胞菌。铜绿假单胞菌肺部定植患者血清中抗铜绿假单胞菌外毒素A的IgG抗体量显著增加（p<0.0001）。相反，定植和未定植CF患者的血清IgG亲和力较低（<10），与30名年龄匹配的健康对照相比有统计学差异（p<0.0001）。6例慢性感染CF患者在半年后采集血清样本，其IgG亲和力无变化（p=0.55）。